a reminder that mice don’t naturally get Alzheimer’s. I’ve worked with many such mouse cells; at some point, i started wondering if i can ever translate this incredible mouse biology to actual human beings. At some point, i got sick of seeing mice be genetically altered, painfully, to an “Alzheimer’s disease phenotype” which of course, makes the pathology different from the vast majority of AD If it works in mice, will it work in a human being, without human organoid models? Well, AD does have a 99% failure rate, and let’s just say we understand the “AD” we model in mice a lot better than in any human being which means: till today, our most common method of modelling the disease is unfortunately painfully unreliable. this is not unique to AD by any means. it just happens to be especially problematic when you’re trying to understand human neuro degeneration, often sporadic, using the closest proxy of *genetic mouse models.* This study is amazing, but it brings me back to some existential questions, and how blindfolded i was to human disease when i was only relying on mouse models. The post mortem data is incredibly helpful and i have nothing against this study. I just can’t help but point out the reality here. Too many cures get lost in translation.