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my observation is that the way we make decisions around acceptable risk in medicine are based around a "reasonableness" standard that may have been common a decade ago, but certainly isn't today.
young people are hilariously risk on with experimental drugs. update accordingly

Mar 15, 02:40
Sorry to be the downer because this is an impressive story in some senses.
But it is ~trivially easy to make a single mRNA vaccine. It's not hard.
I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year.
What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade.
I am happy for this man and his dog. It is impressive.
But y'all are overhyping it.
fda has a lot of challenges facing it over the next 10-15 years- but i do think one of the weirdest residues of our current moment is that they let the cat out of the bag in allowing relatively healthy patients be extremely risk on with peptides, etc. hard to undo that
if i were a regulator forced to clean up this mess, i think the obvious solution is to hit the enablers hard that pushed this stuff downmarket without evidence (jail them!) and then leave the drugs a choose your own adventure for patients that do the work to research
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