No, the Supremacy Clause does not mean, without qualification, that federal law trumps state or local law. The Supremacy Clause means federal law trumps state or local law on those matters in which the federal government has jurisdiction. While the federal government has power over immigration enforcement, it does not have jurisdiction to command the actions of state or local officials—to force them to enforce federal programs, carry out federal duties, or cooperate against their will. Therefore, the Supremacy Clause does not authorize or legitimize such commands. Any attempt by federal officials to command the actions of state or local officials is unconstitutional commandeering under the Tenth Amendment.