When I started at Berkeley in early 2018, I decided to understand deep learning and intelligence, and thought that was once-in-a-decade opportunity. During the pandemic when I started to realize what we were actually embarking on, I realized this is a once-in-a-lifetime challenge. More recently, I have begun to be convinced that it is a once-in-a-history opportunity and challenge to truly understand the scientific, mathematical, and computational nature of intelligence.