Ovaries age 2.5x faster than any other organ. For decades, nobody studied why. A weekly rapamycin pill just changed that. @ColumbiaOBGYN's VIBRANT trial: egg loss dropped 70%, from ~50 to ~15 per month (n=50). VIBRANT II expanding to 1,000 women. Why it works: a @NatureAging atlas mapped 3,455 aging genes in human ovaries and found mTOR hyperactivity as the dominant ovary-specific aging pathway. Rapamycin inhibits mTOR. The biology lined up. Why everyone should care: -> Women live ~5 years longer but spend 25% more of their lives in poor health. -> The 290 genetic loci controlling menopause timing sit in DNA repair pathways that govern aging itself (Ruth et al., @Nature 2021). -> Early menopause predicts accelerated biological aging. -> Menopause timing isn't just a fertility marker. It's a longevity biomarker. In November, the FDA reversed two decades of hormone therapy warnings. The science caught up. We excluded women from aging studies until 2016. The fastest-aging organ in the human body was in women the entire time.