Life Biosciences says it plans to begin first human trials of partial epigenetic reprogramming in 2026, a milestone many in longevity science have been waiting for. The idea is radical but precise: rewind cellular aging without erasing cell identity. Restore function, not reset to zero. If this works in humans, aging stops being something we only manage and starts becoming something we actively reverse. Still, this is the hard part. Mouse miracles are easy. Human safety, dosing, and control are where theories either become medicine or disappear.