This is a job posting for a brand new company and I’d really like your help getting it to the right people :) The history of technology is a short one, and it’s punctuated by a small number of trends. They might be: microprocessors, personal computers, the internet, mobile, and now AI. But it’s hard not to believe that AI is the truly big one. Silicon Valley was the epicenter of the action in exactly 100% of these trends, and amazingly, in 2025, AI is centered here too. Someone needs to document what’s happening here! Someone needs to understand who the people are, and what makes them tick. And do so in a way that does not let them take themselves as seriously as they may want to :) I’m helping launch a very novel type of tech media company, and CEO @patrickmcguire is hiring for three special roles. This is a uniquely ambitious and creative project and is in need of uniquely ambitious and creative talent. If this sounds interesting to you, I suggest you talk to Patrick. Please see the job descriptions attached, and please share and engage if you want to help get this off the ground

Today, we’re announcing @TrustVanta's Series D and new valuation – $4.15 billion – led by @Wellington_Mgmt alongside @sequoia, @ycombinator, @CrowdStrike, @GoldmanSachs, @jpmorgan, @craft_ventures, and @Atlassian. Vanta’s mission is to help businesses earn and prove trust.

Becoming a caregiver for parents with Alzheimer’s… seeing the decline front and center… is actually one of the triggers for people to consider embryo screening for their children APOE e4 is the strongest genetic risk factor for Alzheimer’s e3/e4 (one copy) = ~3x risk e4/e4 (two copies) = ~12x risk We can see this in embryos. We can screen for it. You can prevent your child from inheriting increased risk.

No one talks about how embryo screening can prevent this. APOE e4 is the strongest genetic risk factor for Alzheimer’s e3/e4 (one copy) = ~3x risk e4/e4 (two copies) = ~12x risk We can see this in embryos. We can screen for it. You can prevent your child from inheriting increased risk. You can stop that pain before it begins.

If you’ve never had to take care of a parent/grandparent with Alzheimer’s or Dementia, please count your blessings That shit is NOT for the weak. To see the look in someone’s eyes that took you to school, taught you how to tie a tie, and taught you golf……

what do you most want to know about your baby before they are born?

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One of my siblings took their extremely disabled teen to a Metallica concert & they bought nosebleed seats bc thats all they could afford & they were up there in their seats nice & early & either the band or the venue sent someone to get them & moved them to front row seating Its so sweet this concert will be one of the major highlights of this child’s shortened life

it's craft versus cruft, slop and grift

The nice thing about having a podcast where you interview many of the world's smartest people is the DNA they leave on the mug for your world's smartest people DNA database