Important paper by @EricTopol and colleagues in Nature Metabolism: Obesity as a catalyst for neurodegeneration. Compelling synthesis of how midlife obesity may drive brain-wide reprogramming—impacting neurovascular coupling, BBB integrity, CSF dynamics, metabolism, and myelination—potentially accelerating neurodegenerative vulnerability. Worth a read. @EricTopol @DeepakBhattMD @JavedButlerMD #Obesity #Neurodegeneration #BrainHealth #CardioMetabolic #PrecisionMedicine #PublicHealth #obesity #ozempic